Long-term oncological prognosis after curative-intent liver resection for hepatocellular carcinoma in the young versus the elderly: multicentre propensity score-matching study
Background Hepatocellular carcinoma (HCC) is the most common malignancy in the elderly worldwide, but it is also common among younger individuals in areas with endemic hepatitis B virus infection. The differences in long-term oncological prognosis of young versus elderly patients after R0 liver resection for HCC were explored in this study. Methods Using a Chinese multicentre database, consecutive patients who underwent R0 liver resection for HCC between 2007 and 2019 were analysed retrospectively. After excluding middle-aged (36–69 years old) patients, overall survival [...]
The expression and survival significance of sodium glucose transporters in pancreatic cancer
Abstract Background Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with prognosis are not clear. Thus, we aimed to analyse the expression profile and prognostic significance of SGLT-1 and SGLT-2 in PC. Methods Eighty-eight patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgery in Huashan Hospital, Fudan University, from July 2017 to June 2020 were enrolled in the study. Specimens for immunohistochemistry [...]
Weight Tracking as a Novel Prognostic Marker After Pancreatectomy
Abstract Background Objective measures of post-pancreatectomy weight change for pancreatic ductal adenocarcinoma (PDAC) have not been extensively studied for long-term outcomes. We used weight measurements in our institutional medical record to analyze trends in post-pancreatectomy weight and determine the association with disease status. Methods Pancreatectomies for PDAC (n = 315) and benign indications (n = 111) were identified. Preoperative baseline, minimum postoperative (Min #1), and subsequent postoperative maximum (Max) weights were abstracted. Multivariable Cox hazards regression was conducted to analyze the association between weight [...]
Comparison of oncologic outcomes between open and laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma using data from the KOTUS-BP national database: overcoming selection bias and the necessity of definite indications
Abstract Background Despite the lack of high-level evidence, laparoscopic distal pancreatectomy (LDP) is frequently performed in patients with pancreatic ductal adenocarcinoma (PDAC) owing to advancements in surgical techniques. The aim of this study was to investigate the long-term oncologic outcomes of LDP in patients with PDAC via propensity score matching (PSM) analysis using data from a large-scale national database. Methods A total of 1202 patients who were treated for PDAC via distal pancreatectomy across 16 hospitals were included in the [...]
What is the impact of zinc deficiency for pancreatectomies in patients with pancreatic ductal adenocarcinoma?
Abstract Background and purpose: Zinc is an essential element for human health and plays an important role in metabolic, immunological and other biological processes. The present study was conducted to investigate the association between zinc deficiency (ZD) and the perioperative clinical course in patients with pancreatic ductal adenocarcinoma (PDAC). Methods Of 216 patients with PDAC who underwent elective pancreatectomy between 2013 and 2017 at our institution, 206 patients with sufficient clinical data were retrospectively reviewed. The perioperative variables were compared and [...]
Surgical Treatment of Splenic Artery Pseudoaneurysm with Digestive Tract Communication – Presentation of Two Cases
Rezumat: Spleno-pancreatectomia efectuată pentru tratamentul pseudo- anevrismelor arterei splenice localizate la nivelul unui pseudochist pancreatic ce comunică cu tubul digestiv (stomac sau colon) reprezintă una din indicaţiile rare, puţine astfel de proceduri fiind descrise în literatură. Tratamentul pseudo-anevrismelor peri- pancreatice este complex şi dificil. Tratamentul chirurgical este curativ şi poate include rezecţia altor organe. Intervenţiile chirurgi- cale pot fi executate in condiţi de urgenţă, dacă pacientul prezintă sângerare cataclismică sau în condiţii elective în cazul în care [...]